Dylan Dyke, a 12-year-old boy with autism, spends time with his ducks, Nibbles, left, and Bill, outside his home in Michigan on Aug. 2, 2018. (Cory Morse/The Grand Rapids Press via AP)

Dylan Dyke, a 12-year-old boy with autism, spends time with his ducks, Nibbles, left, and Bill, outside his home in Michigan on Aug. 2, 2018. (Cory Morse/The Grand Rapids Press via AP)

Infants should be tested for autism if older siblings are diagnosed, Canadian study suggests

Blood test for infants with sibling who’s been diagnosed would get information to families earlier

Canadian researchers have led a study suggesting infants be tested for autism spectrum disorder before symptoms appear if an older sibling has already been diagnosed with the neurobiological condition.

The odds of a younger sibling having autism are up to 20 per cent, but most children miss out on early intervention for challenges in behaviour and communication because they’re often not diagnosed until age four, previous studies have shown.

Research by Dr. Stephen Scherer, senior scientist and director of the Centre for Applied Genomics at the Hospital for Sick Children in Toronto, and Dr. Lonnie Zwaigenbaum, a professor of pediatrics at the University of Alberta, found a standard blood test analyzing the DNA of infants with a sibling who’s been diagnosed with autism would provide earlier information for families.

The findings were published Thursday in the journal Nature Communications.

They involve 288 infant siblings from Canada and the United States showing that by age three, 157 of the children were either diagnosed with autism spectrum disorder or developing atypically. Of the 157 children, seven per cent were carrying a gene that put them at a very high risk of developing autism.

RELATED: New study suggests autism overdiagnosed, Canadian expert says

Of the seven per cent of kids, 50 per cent were diagnosed with autism by age three and an additional 35 per cent had other developmental challenges.

Scherer said families of autistic children are often concerned about whether a sibling could also be at risk.

“It’s the number one question families have and no one’s ever wrapped any statistics around that and that’s what we present for the first time, with this paper,” he said.

Further genetic testing looking at the entire genome, beyond a blood test called microarray analysis, is being conducted with all the families in the study in hopes it will provide more information about the risk of autism, Scherer said.

The participants were part of the Baby Siblings Research Consortium, which includes independent research groups in Canada, the United States and Europe, though this study included 10 sites in North America, four of them in Canada, Zwaigenbaum said of the testing that is part of an ongoing decade-long research project looking at behavioural predictors of autism.

“Based on the findings of the study, we’re suggesting that the test be focused on younger siblings,” he said. “It could be informative at a time where we’re not likely to see any behavioural signs. So it provides an option for presymptomatic testing to identify infants at highest risk.”

READ MORE: Autism support dog refused bus access for being a ‘pet’

Families who are informed about a younger child’s risk of autism could initiate strategies to help them develop early communication skills before assessment of behaviour by a specialist and intervention by a therapist as part of a cost-effective approach to care, Zwaigenbaum said.

“I think we may be moving to an exciting new time where both biomarkers and developmental surveillance can provide complementary information to help us identify infants at risk.”

Camille Bains, The Canadian Press

Like us on Facebook and follow us on Twitter

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Actions of Vancouver Island RCMP emergency response team members prevented a potential head-on collision accident on the Trans-Canada Highway on Jan. 19, says Nanaimo RCMP. (News Bulletin file)
Eight cars evade vehicle driving on wrong side of highway, says Nanaimo RCMP

Incident occurred near Trans-Canada Highway-Morden Road intersection earlier this week

VIU’s health and science centre. (Vancouver Island University photo)
VIU to train 72 health-care assistants to work with seniors

B.C. Ministry of Health announces details of health career access program

City of Nanaimo’s council chambers, the Shaw Auditorium at the Vancouver Island Conference Centre. (News Bulletin file photo)
LETTER TO THE EDITOR: City council should save Nanaimo before trying to save planet

City councillors aren’t at the G7 table, they represent a small B.C. city, says letter writer

Terry Keogh, an RDN Transit driver, used his paramedic skills the morning of Jan. 22 after coming across an unconscious woman along his route in downtown Nanaimo. (RDN Transit photo)
RDN Transit driver stops his bus and helps get overdosing woman breathing again

Former EMT from Ireland performed CPR on a woman in downtown Nanaimo on Friday

Peter Crema and Harmony Gray (from left), past participants of the Nanaimo Art Gallery’s Code Switching teen art group, at work in ArtLab in 2019. The NAG will be expanding the space thanks to a $75,000 arts infrastructure program grant. (Bulletin file photo)
Nanaimo Art Gallery, Nanaimo Aboriginal Centre receive new arts infrastructure funding

Province announces recipients of funding through B.C. Arts Council program

Emergency crews were called to a crash involving a hatchback and a taxi minivan at the intersection of Fitzwilliam, Pine and Third streets on Friday afternoon. (Greg Sakaki/News Bulletin)
Driver hurt as taxi and hatchback crash in Nanaimo

Collision happened Friday at intersection of Fitzwilliam, Pine and Third streets

A video posted to social media by Chilliwack resident Rob Iezzi shows a teenager getting kicked in the face after being approached by three suspects on Friday, Jan. 22, 2021. (YouTube/Rob i)
VIDEO: Security cameras capture ‘just one more assault’ near B.C. high school

Third high-school related assault captured by Chilliwack resident’s cameras since beginning of 2021

FILE - In this Feb. 14, 2017, file photo, Oklahoma State Rep. Justin Humphrey prepares to speak at the State Capitol in Oklahoma City. A mythical, ape-like creature that has captured the imagination of adventurers for decades has now become the target of Rep. Justin Humphrey. Humphrey, a Republican House member has introduced a bill that would create a Bigfoot hunting season, He says issuing a state hunting license and tag could help boost tourism. (Steve Gooch/The Oklahoman via AP, File)
Oklahoma lawmaker proposes ‘Bigfoot’ hunting season

A Republican House member has introduced a bill that would create a Bigfoot hunting season

Economic Development and Official Languages Minister Melanie Joly responds to a question in the House of Commons Monday November 23, 2020 in Ottawa. THE CANADIAN PRESS/Adrian Wyld
Federal minister touts need for new B.C. economic development agency

Last December’s federal economic update promised a stimulus package of about $100 billion this year

FILE - In this Nov. 20, 2017, file photo, Larry King attends the 45th International Emmy Awards at the New York Hilton, in New York. Former CNN talk show host King has been hospitalized with COVID-19 for more than a week, the news channel reported Saturday, Jan. 2, 2021. CNN reported the 87-year-old King contracted the coronavirus and was undergoing treatment at Cedars-Sinai Medical Center in Los Angeles. (Photo by Andy Kropa/Invision/AP, File)
Larry King, broadcasting giant for half-century, dies at 87

King conducted an estimated 50,000 on-air interviews

Comox Valley RCMP are looking for witnesses after the theft of a generator worth thousands of dollars. Photo supplied
RCMP asking Vancouver Island residents to watch for stolen generator

Vehicle may have been travelling on Highway 19

BC Coroners Service is currently investigating a death at Canoe Cove Marina and Boatyard in North Saanich. (Black Press Media File)
Drowning death in North Saanich likely B.C.’s first in for 2021

Investigation into suspected drowning Monday night continues

Kimberly Proctor, 18, was murdered in 2010. Her family has spent many of the years since pushing for a law in her honour, that they say would help to prevent similar tragedies. (Courtesy of Jo-Anne Landolt)
Proposed law honouring murdered B.C. teen at a standstill, lacks government support

Ministry of Mental Health and Addictions has concerns with involuntary detainment portion of act

Chief Public Health Officer Theresa Tam speaks during a daily briefing in Ottawa. (THE CANADIAN PRESS/Adrian Wyld)
31 cases of COVID-19 variants detected in Canada: Health officials

Dr. Theresa Tam made announces 13 more variant COVID-19 cases in Canada

Most Read